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Article

Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Bochtler Petra, Kröger Andrea, Schirmbeck Reinhold, Reimann Jörg

Abstract excerpt

We investigated the negative effect of type I IFN (IFN-I) on the priming of specific CD8 T cell immunity. Priming of murine CD8 T cells is down-modulated if Ag is codelivered with IFN-I-inducing polyinosinic:polycytidylic acid (pI/C) that induces (NK cell- and T/B cell-independent) acute changes in the composition and surface phenotype of dendritic cells (DC). In wild-type but not IFN-I receptor-deficient mice,...

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PMID: 18641299
DOI: 10.4049/jimmunol.181.3.1633

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APC
BST2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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