Article
IFN-alpha in the generation of dendritic cells for cancer immunotherapy.
Handbook of experimental pharmacology - 1 Jan 2009
Santini Stefano Maria, Lapenta Caterina, Santodonato Laura, D'Agostino Giuseppina, Belardelli Filippo, Ferrantini Maria
Abstract excerpt
Dendritic cells (DCs) play a crucial role in linking innate and adaptive immunity, by virtue of their unique ability to take up and process antigens in the peripheral blood and tissues and, upon migration to draining lymph nodes, to present antigen to resting lymphocytes. Notably, these DC functions are modulated by cytokines and chemokines controlling the activation and maturation of these cells, thus shaping...
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