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Article

Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2012

Simmons Daimon P, Wearsch Pamela A, Canaday David H, Meyerson Howard J, Liu Yi C, Wang Ying, Boom W Henry, Harding Clifford V

Abstract excerpt

Microbial molecules or cytokines can stimulate dendritic cell (DC) maturation, which involves DC migration to lymph nodes and enhanced presentation of Ag to launch T cell responses. Microbial TLR agonists are the most studied inducers of DC maturation, but type I IFN (IFN-I) also promotes DC maturation. In response to TLR stimulation, DC maturation involves a burst of Ag processing with enhanced expression of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22371391
DOI: 10.4049/jimmunol.1101313
PMCID: PMC3311734

Genes

CIITA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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