Article
Mannose-binding lectin genotypes in susceptibility to community-acquired pneumonia.
Chest - 1 Dec 2008
Endeman Henrik, Herpers Bjorn L, de Jong Ben A W, Voorn G Paul, Grutters Jan C, van Velzen-Blad Heleen, Biesma Douwe H
Abstract excerpt
BACKGROUND: Community-acquired pneumonia (CAP) is most frequently caused by Streptococcus pneumoniae, Haemophilus influenzae, atypical pathogens, and respiratory viruses. Susceptibility to CAP can be increased by single-nucleotide polymorphisms (SNPs) within the mannose-binding lectin (MBL) gene. We questioned whether MBL polymorphisms are associated with the susceptibility to and outcome of CAP and its most...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cohort Studies
- Community-Acquired Infections
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Mannose-Binding Lectin
- Middle Aged
- Pneumonia, Bacterial
- Pneumonia, Viral
- Polymorphism, Single Nucleotide
- Treatment Outcome