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Article

Mannose-binding lectin genotype is associated with respiratory disease in young children: A multicenter cohort study.

Pediatric pulmonology - 1 Nov 2022

Ruffles Tom, Basu Kaninika, Inglis Sarah K, Bremner Stephen, Rabe Heike, Memon Anjum, Seddon Paul, Tavendale Roger, Palmer Colin N A, Mukhopadhyay Somnath, Fidler Katy

Abstract excerpt

BACKGROUND: Mannose-binding lectin (MBL) is an important component of the innate immune system. Polymorphisms in the MBL2 gene and promoter region are directly associated with MBL-deficiency. We sought to determine the association between MBL genotype on the frequency of common childhood respiratory infections, respiratory symptoms, and atopic outcomes in early childhood. METHODS: MBL2 gene variants were analyzed...

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PMID: 35949104
DOI: 10.1002/ppul.26109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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