Article
The role of mannose-binding lectin in pneumococcal infection.
The European respiratory journal - 1 Jan 2013
García-Laorden M Isabel, Rodríguez de Castro Felipe, Solé-Violán Jordi, Payeras Antoni, Briones M Luisa, Borderías Luis, Aspa Javier, Blanquer José, Rajas Olga, Marcos-Ramos J Alberto, Herrera-Ramos Estefanía, García-Bello Miguel A, Noda Judith, Ferrer José M, Rello Jordi, Rodríguez-Gallego Carlos
Abstract excerpt
The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four...
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