Article
Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Aug 2008
Eisen Damon P, Dean Melinda M, Boermeester Marja A, Fidler Katy J, Gordon Anthony C, Kronborg Gitte, Kun Jürgen F J, Lau Yu Lung, Payeras Antonis, Valdimarsson Helgi, Brett Stephen J, Ip W K Eddie, Mila Joan, Peters Mark J, Saevarsdottir Saedis, van Till J W Oliver, Hinds Charles J, McBryde Emma S
Abstract excerpt
BACKGROUND: Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, and associations with sepsis outcomes have not been subjected to multivariable analysis. METHODS: We reanalyzed MBL results in a large cohort with use of individual data from 4 studies involving a total of...
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