Article
Genetic susceptibility to pneumonia.
Clinics in chest medicine - 1 Mar 2005
Waterer Grant W, Wunderink Richard G
Abstract excerpt
The persistent mortality from community-acquired pneumonia may be explained by genetic predisposition. Specific mutations or polymorphisms in host response genes that are associated with adverse outcomes from infection can be grouped into four categories: antigen recognition, proinflammatory responses, anti-inflammatory responses, and effector mechanisms. Mannose-binding lectin polymorphisms have a more dominant...
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