Article
MBL genotype and risk of invasive pneumococcal disease: a case-control study.
Lancet (London, England) - 4 May 2002
Roy Suchismita, Knox Kyle, Segal Shelley, Griffiths David, Moore Catrin E, Welsh Kenneth I, Smarason Alex, Day Nicholas P, McPheat William L, Crook Derrick W, Hill Adrian V S
Abstract excerpt
BACKGROUND: Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innate host immunity that activates the complement pathway and directly opsonises some infectious pathogens. Mutations in three codons in the MBL gene have been identified, and...
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