Article
Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia.
Human immunology - 1 Feb 2009
Herpers Bjorn L, Yzerman Ed P F, de Jong Ben A W, Bruin Jacob P, Lettinga Kamilla D, Kuipers Saskia, Den Boer Jeroen W, van Hannen Erik J, Rijkers Ger T, van Velzen-Blad Heleen, de Jongh Bartelt M
Abstract excerpt
Polymorphisms leading to deficiency of mannose-binding lectin (MBL) are associated with predisposition to infection. However, MBL deficiency can be protective against intracellular pathogens that use MBL to enter host cells. The role of MBL genotype and activity in infection with the intracellular pathogen Legionella pneumophila was studied in a large outbreak of legionellosis at a Dutch flower show. A total of...
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