Article
Gene polymorphisms of mannose-binding lectin confer susceptibility to Pneumocystis pneumonia in HIV-infected patients.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Nov 2015
Yanagisawa Kunio, Ogawa Yoshiyuki, Uchiumi Hideki, Gohda Fumito, Mawatari Momoko, Ishizaki Takuma, Mitsui Takeki, Yokohama Akihiko, Handa Hiroshi, Tsukamoto Norifumi, Nojima Yoshihisa
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) plays an important role in innate immunity. The aim of this study was to determine whether genetic variants of MBL confer susceptibility to Pneumocystis pneumonia (PCP) in patients with advanced human immunodeficiency virus (HIV) infections. OBJECTIVE: HIV patients (n = 53) having CD4 counts <200/μL who were admitted to our hospital were analyzed. Of these 53 patients, 30...
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