Article
Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population.
Cancer epidemiology - 1 Apr 2011
Jones Nathan R, Spratt Thomas E, Berg Arthur S, Muscat Joshua E, Lazarus Philip, Gallagher Carla J
Abstract excerpt
BACKGROUND: The formation of bulky DNA adducts caused by diol epoxide derivatives of polycyclic aromatic hydrocarbons has been associated with tobacco-induced cancers, and inefficient repair of such adducts by the nucleotide excision repair (NER) system has been linked to increased risk of tobacco-induced lung and head and neck (H&N) cancers. The human excision repair cross-complementation group 1 (ERCC1) protein...
Topics
- Case-Control Studies
- DNA Repair
- DNA-Binding Proteins
- Endonucleases
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Head and Neck Neoplasms
- Humans
- Lung Neoplasms
- Male
- Middle Aged