Article
Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes.
PloS one - 1 Jan 2012
Yu Hongping, Zhao Hui, Wang Li-E, Liu Zhensheng, Li Donghui, Wei Qingyi
Abstract excerpt
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair phenotype that is associated with cancer risk. In this study, we explored associations between genotypes of base-excision repair genes (PARP1 Val762Ala, APEX1 Asp148Glu, and XRCC1 Arg399Gln) and in vitro BPDE-induced DNA adducts in cultured...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adult
- Aged
- Cell Line
- Cells, Cultured
- DNA Adducts
- DNA Repair
- Female
- Genetic Association Studies
- Genotype
- Humans