Article
Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis.
Cancer research - 15 Jul 2008
Inoue-Narita Tae, Hamada Koichi, Sasaki Takehiko, Hatakeyama Sachiko, Fujita Sachiko, Kawahara Kohichi, Sasaki Masato, Kishimoto Hiroyuki, Eguchi Satoshi, Kojima Itaru, Beermann Friedrich, Kimura Tetsunori, Osawa Masatake, Itami Satoshi, Mak Tak Wah, Nakano Toru, Manabe Motomu, Suzuki Akira
Abstract excerpt
Phosphate and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene inactivated in numerous sporadic cancers, including melanomas. To analyze Pten functions in melanocytes, we used the Cre-loxP system to delete Pten specifically in murine pigment-producing cells and generated DctCrePten(flox/flox) mice. Half of DctCrePten(flox/flox) mice died shortly after birth with enlargements of the...
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