Article
MC1R is a potent regulator of PTEN after UV exposure in melanocytes.
Molecular cell - 22 Aug 2013
Cao Juxiang, Wan Lixin, Hacker Elke, Dai Xiangpeng, Lenna Stefania, Jimenez-Cervantes Celia, Wang Yongjun, Leslie Nick R, Xu George X, Widlund Hans R, Ryu Byungwoo, Alani Rhoda M, Dutton-Regester Ken, Goding Colin R, Hayward Nicholas K, Wei Wenyi, Cui Rutao
Abstract excerpt
The individuals carrying melanocortin-1 receptor (MC1R) variants, especially those associated with red hair color, fair skin, and poor tanning ability (RHC trait), are more prone to melanoma; however, the underlying mechanism is poorly defined. Here, we report that UVB exposure triggers phosphatase and tensin homolog (PTEN) interaction with wild-type (WT), but not RHC-associated MC1R variants, which protects PTEN...
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