Article
Genetics of dark skin in mice.
Genes & development - 15 Jan 2003
Fitch Karen R, McGowan Kelly A, van Raamsdonk Catherine D, Fuchs Helmut, Lee Daekee, Puech Anne, Hérault Yann, Threadgill David W, Hrabé de Angelis Martin, Barsh Gregory S
Abstract excerpt
Chemical mutagenesis in the mouse is a powerful approach for phenotype-driven genetics, but questions remain about the efficiency with which new mutations ascertained by their phenotype can be localized and identified, and that knowledge applied to a specific biological problem. During a global screen for dominant phenotypes in about 30,000 animals, a novel class of pigmentation mutants were identified by dark...
Topics
- Amino Acid Sequence
- Animals
- Chromosome Mapping
- ErbB Receptors
- Genes, Dominant
- Homozygote
- Humans
- Keratins
- Melanocytes
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation