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Article

Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche

23 Dec 2004

Abstract excerpt

Hair graying is the most obvious sign of aging in humans, yet its mechanism is largely unknown. Here, we used melanocyte-tagged transgenic mice and aging human hair follicles to demonstrate that hair graying is caused by defective self-maintenance of melanocyte stem cells. This process is accelerated dramatically with Bcl2 deficiency, which causes selective apoptosis of melanocyte stem cells, but not of...

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PMID: 15618488
DOI: 10.1126/science.1099593

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