Article
Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis.
Pigment cell & melanoma research - 1 Feb 2008
Kumano Keiki, Masuda Shigeo, Sata Masataka, Saito Toshiki, Lee Suk-Young, Sakata-Yanagimoto Mamiko, Tomita Taisuke, Iwatsubo Takeshi, Natsugari Hideaki, Kurokawa Mineo, Ogawa Seishi, Chiba Shigeru
Abstract excerpt
Notch signaling affects a variety of mammalian stem cells, but there has been limited evidence that a specific Notch molecule regulates adult stem cells. Recently, it was reported that the reduced Notch signaling initiated at the embryonic stage results in a gradual hair graying phenotype after birth. Here we demonstrate that the oral administration of a gamma-secretase inhibitor (GSI) to wild-type adult C57/Bl6...
Topics
- Amyloid Precursor Protein Secretases
- Animals
- Cell Differentiation
- Cell Proliferation
- Embryo Culture Techniques
- Enzyme Inhibitors
- Gene Expression Regulation, Developmental
- Genotype
- Hair Color
- Hair Follicle
- Homeostasis
- Melanocytes