Article
Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project.
European journal of human genetics : EJHG - 1 Dec 2008
Grisoni Marie-Lise, Proust Carole, Alanne Mervi, DeSuremain Maylis, Salomaa Veikko, Kuulasmaa Kari, Cambien François, Nicaud Viviane, Stegmayr Birgitta, Virtamo Jarmo, Shields Denis, Kee Frank, Tiret Laurence, Evans Alun, Tregouet David-Alexandre
Abstract excerpt
Interleukin-18 (IL-18) is a key inflammatory molecule suspected of being involved in the etiology of cardiovascular diseases (CVD). Five single nucleotide polymorphisms (SNPs) capturing the common genetic variation of the IL-18 gene (tag SNPs) were genotyped in five European prospective CVD cohorts including 1933 cases and 1938 non-cases as part of the MORGAM Project. Not a single SNP was found associated with...
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