Article
Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project.
BMC medical genetics - 27 May 2009
Grisoni Marie-Lise, Proust Carole, Alanne Mervi, Desuremain Maylis, Salomaa Veikko, Kuulasmaa Kari, Cambien François, Nicaud Viviane, Wiklund Per-Gunnar, Virtamo Jarmo, Kee Frank, Tiret Laurence, Evans Alun, Tregouet David-Alexandre
Abstract excerpt
BACKGROUND: Interleukin-18 is a pro-inflammatory cytokine suspected to be associated with atherosclerosis and its complications. We had previously shown that one single nucleotide polymorphism (SNP) of the IL18 gene was associated with cardiovascular disease (CVD) through an interaction with smoking. As a further step for elucidating the contribution of the IL-18 pathway to the etiology of CVD, we here...
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