Article
Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki Sudden Death Study.
European heart journal - 1 Dec 2009
Hernesniemi Jussi A, Karhunen Pekka J, Oksala Niku, Kähönen Mika, Levula Mari, Rontu Riikka, Ilveskoski Erkki, Kajander Olli, Goebeler Sirkka, Viiri Leena E, Hurme Mikko, Lehtimäki Terho
Abstract excerpt
AIMS: The interleukin 18 (IL-18) gene has a single nucleotide promoter region (-137) G-to-C polymorphism (rs187238) which leads to attenuated transcriptional activity of the gene and to lower production of pro-atherogenic IL-18. The C allele of this polymorphism is associated with a lower risk of sudden cardiac death (SCD). We examined the process by which this polymorphism alters the risk of SCD and coronary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.