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Article

A common interleukin 18 haplotype is associated with higher body mass index in subjects with diabetes and coronary heart disease.

Metabolism: clinical and experimental - 1 May 2007

Thompson Simon R, Sanders Julie, Stephens Jeffrey W, Miller George J, Humphries Steve E

Abstract excerpt

The pleiotropic proinflammatory cytokine, interleukin 18, plays a role in innate immunity and, based on mouse models, influences obesity. We investigated variation within the IL18 gene and its effect on markers of the metabolic syndrome. A tagging single nucleotide polymorphism set of 5 SNPs for the gene encoding interleukin 18 was selected and genotype was determined in 3 separate studies. In 2775 healthy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17445542
DOI: 10.1016/j.metabol.2006.12.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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