Deciphering the genetics of hereditary non-syndromic colorectal cancer.

doi:10.1038/ejhg.2008.129

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Article

Deciphering the genetics of hereditary non-syndromic colorectal cancer.

European journal of human genetics : EJHG - 1 Dec 2008

Papaemmanuil Eli, Carvajal-Carmona Luis, Sellick Gabrielle S, Kemp Zoe, Webb Emily, Spain Sarah, Sullivan Kate, Barclay Ella, Lubbe Steven, Jaeger Emma, Vijayakrishnan Jayaram, Broderick Peter, Gorman Maggie, Martin Lynn, Lucassen Anneke, Bishop D Timothy, Evans D Gareth, Maher Eamonn R, Steinke Verena, Rahner Nils, Schackert Hans K, Goecke Timm O, Holinski-Feder Elke, Propping Peter, Van Wezel Tom, Wijnen Juul, Cazier Jean-Baptiste, Thomas Huw, Houlston Richard S, Tomlinson Ian

Abstract excerpt

Previously we have localized to chromosome 3q21-q24, a predisposition locus for colorectal cancer (CRC), through a genome-wide linkage screen (GWLS) of 69 families without familial adenomatous polyposis or hereditary non-polyposis CRC. To further investigate Mendelian susceptibility to CRC, we extended our screen to include a further GWLS of an additional 34 CRC families. We also searched for a disease gene at...

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PMID: 18628789
DOI: 10.1038/ejhg.2008.129

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