Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia.

doi:10.1038/bjc.2017.240

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Article

Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia.

British journal of cancer - 5 Sept 2017

Schubert Stephanie A, Ruano Dina, Elsayed Fadwa A, Boot Arnoud, Crobach Stijn, Sarasqueta Arantza Farina, Wolffenbuttel Bruce, van der Klauw Melanie M, Oosting Jan, Tops Carli M, van Eijk Ronald, Vasen Hans Fa, Vossen Rolf Ham, Nielsen Maartje, Castellví-Bel Sergi, Ruiz-Ponte Clara, Tomlinson Ian, Dunlop Malcolm G, Vodicka Pavel, Wijnen Juul T, Hes Frederik J, Morreau Hans, de Miranda Noel Fcc, Sijmons Rolf H, van Wezel Tom

Abstract excerpt

BACKGROUND: A substantial fraction of familial colorectal cancer (CRC) and polyposis heritability remains unexplained. This study aimed to identify predisposing loci in patients with these disorders. METHODS: Homozygosity mapping was performed using 222 563 SNPs in 302 index patients with various colorectal neoplasms and 3367 controls. Linkage analysis, exome and whole-genome sequencing were performed in a family...

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PMID: 28742792
DOI: 10.1038/bjc.2017.240
PMCID: PMC5589990

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MIA3

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