Article
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
Human molecular genetics - 1 Sept 2014
Whiffin Nicola, Hosking Fay J, Farrington Susan M, Palles Claire, Dobbins Sara E, Zgaga Lina, Lloyd Amy, Kinnersley Ben, Gorman Maggie, Tenesa Albert, Broderick Peter, Wang Yufei, Barclay Ella, Hayward Caroline, Martin Lynn, Buchanan Daniel D, Win Aung Ko, Hopper John, Jenkins Mark, Lindor Noralane M, Newcomb Polly A, Gallinger Steve, Conti David, Schumacher Fred, Casey Graham, Liu Tao, Campbell Harry, Lindblom Annika, Houlston Richard S, Tomlinson Ian P, Dunlop Malcolm G
Abstract excerpt
To identify common variants influencing colorectal cancer (CRC) risk, we performed a meta-analysis of five genome-wide association studies, comprising 5626 cases and 7817 controls of European descent. We conducted replication of top ranked single nucleotide polymorphisms (SNPs) in additional series totalling 14 037 cases and 15 937 controls, identifying a new CRC risk locus at 10q24.2 [rs1035209; odds ratio (OR)...
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