Article
Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer.
Journal of medical genetics - 1 Oct 2010
Neklason Deborah W, Tuohy Thérèse M, Stevens Jeffery, Otterud Brith, Baird Lisa, Kerber Richard A, Samowitz Wade S, Kuwada Scott K, Leppert Mark F, Burt Randall W
Abstract excerpt
BACKGROUND: Colorectal cancer is the fourth most common type of cancer and the second most common cause of cancer death. Fewer than 5% of colon cancers arise in the presence of a clear hereditary cancer condition; however, current estimates suggest that an additional 15-25% of colorectal cancers arise on the basis of unknown inherited factors. AIM: To identify additional genetic factors responsible for colon...
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