A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis.

doi:10.1371/journal.pone.0101178

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Article

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis.

PloS one - 1 Jan 2014

Real Luis M, Ruiz Agustín, Gayán Javier, González-Pérez Antonio, Sáez María E, Ramírez-Lorca Reposo, Morón Francisco J, Velasco Juan, Marginet-Flinch Ruth, Musulén Eva, Carrasco José M, Moreno-Rey Concha, Vázquez Enrique, Chaves-Conde Manuel, Moreno-Nogueira Jose A, Hidalgo-Pascual Manuel, Ferrero-Herrero Eduardo, Castellví-Bel Sergi, Castells Antoni, Fernandez-Rozadilla Ceres, Ruiz-Ponte Clara, Carracedo Angel, González Beatriz, Alonso Sergio, Perucho Manuel

Abstract excerpt

BACKGROUND: Non-hereditary colorectal cancer (CRC) is a complex disorder resulting from the combination of genetic and non-genetic factors. Genome-wide association studies (GWAS) are useful for identifying such genetic susceptibility factors. However, the single loci so far associated with CRC only represent a fraction of the genetic risk for CRC development in the general population. Therefore, many other...

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PMID: 24978480
DOI: 10.1371/journal.pone.0101178
PMCID: PMC4076321

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