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Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan.

Human molecular genetics - 1 Oct 2006

Kemp Zoe, Carvajal-Carmona Luis, Spain Sarah, Barclay Ella, Gorman Margaret, Martin Lynn, Jaeger Emma, Brooks Neil, Bishop D Timothy, Thomas Huw, Tomlinson Ian, Papaemmanuil Elli, Webb Emily, Sellick Gabrielle S, Wood Wendy, Evans Gareth, Lucassen Anneke, Maher Eamonn R, Houlston Richard S

Abstract excerpt

To identify a novel susceptibility gene for colorectal cancer (CRC), we conducted a genome-wide linkage analysis of 69 pedigrees segregating colorectal neoplasia in which involvement of known loci had been excluded, using a high-density single nucleotide polymorphism (SNP) array containing 10,204 markers. Multipoint linkage analyses were undertaken using both non-parametric (model-free) and parametric...

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PMID: 16923799
DOI: 10.1093/hmg/ddl231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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