Article
A two-phase case-control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22.
British journal of cancer - 6 Sept 2011
Abulí A, Fernández-Rozadilla C, Giráldez M D, Muñoz J, Gonzalo V, Bessa X, Bujanda L, Reñé J M, Lanas A, García A M, Saló J, Argüello L, Vilella A, Carreño R, Jover R, Xicola R M, Llor X, Carvajal-Carmona L, Tomlinson I P M, Kerr D J, Houlston R S, Piqué J M, Carracedo A, Castells A, Andreu M, Ruiz-Ponte C, Castellví-Bel S
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is the second cause of cancer-related death in the Western world. Much of the CRC genetic risk remains unidentified and may be attributable to a large number of common, low-penetrance genetic variants. Genetic linkage studies in CRC families have reported additional association with regions 9q22-31, 3q21-24, 7q31, 11q, 14q and 22q. There are several plausible candidate genes...
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