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Article

Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis.

Cancer research - 1 Nov 2008

Neklason Deborah W, Kerber Richard A, Nilson David B, Anton-Culver Hoda, Schwartz Ann G, Griffin Constance A, Lowery Jan T, Schildkraut Joellen M, Evans James P, Tomlinson Gail E, Strong Louise C, Miller Alexander R, Stopfer Jill E, Finkelstein Dianne M, Nadkarni Prakash M, Kasten Carol H, Mineau Geraldine P, Burt Randall W

Abstract excerpt

Present investigations suggest that approximately 30% of colorectal cancer cases arise on the basis of inherited factors. We hypothesize that the majority of inherited factors are moderately penetrant genes, common in the population. We use an affected sibling pair approach to identify genetic regions that are coinherited by siblings with colorectal cancer. Individuals from families with at least two siblings...

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Identifiers

PMID: 18974144
DOI: 10.1158/0008-5472.CAN-08-1376
PMCID: PMC2927856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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