Article
Evolution and transmission of stable CTL escape mutations in HIV infection.
Nature - 19 Jul 2001
Goulder P J, Brander C, Tang Y, Tremblay C, Colbert R A, Addo M M, Rosenberg E S, Nguyen T, Allen R, Trocha A, Altfeld M, He S, Bunce M, Funkhouser R, Pelton S I, Burchett S K, McIntosh K, Korber B T, Walker B D
Abstract excerpt
Increasing evidence indicates that potent anti-HIV-1 activity is mediated by cytotoxic T lymphocytes (CTLs); however, the effects of this immune pressure on viral transmission and evolution have not been determined. Here we investigate mother-child transmission in the setting of human leukocyte antigen (HLA)-B27 expression, selected for analysis because it is associated with prolonged immune containment in adult...
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