Article

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

2021-09-24

Abstract excerpt

<h4>Background</h4> Antigen-specific T cell impairment is observed in chronic infections. CD4+ T cells are diverse in phenotype and function; how their different lineages are impacted by inhibitory immune checkpoints (IC) is unknown. <h4>Methods</h4> We examined IC expression and function in HIV-specific CD4+ T cells of viremic individuals prior to ART initiation and persons with spontaneous or therapy-induced v...

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Literature Corpus work: f4f2117f-7246-5a07-b534-d6fbb3668b0f
DOI: 10.1101/2021.09.23.461484

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