Article
Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.
Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2009
Rakhmanov Mirzokhid, Keller Baerbel, Gutenberger Sylvia, Foerster Christian, Hoenig Manfred, Driessen Gertjan, van der Burg Mirjam, van Dongen Jacques J, Wiech Elisabeth, Visentini Marcella, Quinti Isabella, Prasse Antje, Voelxen Nadine, Salzer Ulrich, Goldacker Sigune, Fisch Paul, Eibel Hermann, Schwarz Klaus, Peter Hans-Hartmut, Warnatz Klaus
Abstract excerpt
The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell populatio...
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