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Article

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma

14 Jul 2008

Abstract excerpt

In mantle cell lymphoma (MCL) and some cases of multiple myeloma (MM), cyclin D1 expression is deregulated by chromosome translocations involving the immunoglobulin heavy chain (IgH) locus. To evaluate the mechanisms responsible, gene targeting was used to study long-distance gene regulation. Remarkably, these targeted cell lines lost the translocated chromosome (t(11;14)). In these MCL and MM cells, the...

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PMID: 18625744
DOI: 10.1084/jem.20072102

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Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphomaPMID 18625744Read ↗

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