Article
Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.
Blood - 15 Jun 2008
Wlodarska Iwona, Dierickx Daan, Vanhentenrijk Vera, Van Roosbroeck Katrien, Pospísilová Helena, Minnei Francesca, Verhoef Gregor, Thomas José, Vandenberghe Peter, De Wolf-Peeters Chris
Abstract excerpt
The genetics of t(11;14)(q13;q32)/cyclin D1-negative mantle cell lymphoma (MCL) is poorly understood. We report here 8 MCL cases lacking t(11;14) or variant CCND1 rearrangement that showed expression of cyclin D1 (2 cases), D2 (2 cases), and D3 (3 cases). One case was cyclin D negative. Cytogenetics and fluorescence in situ hybridization detected t(2;12)(p11;p13)/IGK-CCND2 in one of the cyclin D2-positive cases...
Topics
- Adult
- Aged
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 14
- Cyclin D2
- Cyclin D3
- Cyclins
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Humans
- Immunohistochemistry