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Article

Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.

Blood - 15 Jun 2008

Wlodarska Iwona, Dierickx Daan, Vanhentenrijk Vera, Van Roosbroeck Katrien, Pospísilová Helena, Minnei Francesca, Verhoef Gregor, Thomas José, Vandenberghe Peter, De Wolf-Peeters Chris

Abstract excerpt

The genetics of t(11;14)(q13;q32)/cyclin D1-negative mantle cell lymphoma (MCL) is poorly understood. We report here 8 MCL cases lacking t(11;14) or variant CCND1 rearrangement that showed expression of cyclin D1 (2 cases), D2 (2 cases), and D3 (3 cases). One case was cyclin D negative. Cytogenetics and fluorescence in situ hybridization detected t(2;12)(p11;p13)/IGK-CCND2 in one of the cyclin D2-positive cases...

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Share to Chromosomes, Human, Pair 11
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin D2

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Source

Identifiers

PMID: 18391076
DOI: 10.1182/blood-2007-10-118794

Genes

MYCN
CCND2
CCND3
CCND1
IGH
IGK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.PMID 18391076Read ↗

t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform.Semantic proximity Read ↗

CCND2 rearrangements are the most frequent genetic events in cyclin D1− mantle cell lymphomaSemantic proximity Read ↗

Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation.Semantic proximity Read ↗

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1− mantle cell lymphomaSemantic proximity Read ↗

Clinical, Morphologic, Phenotypic, and Genetic Evidence of Cyclin D1-positive Diffuse Large B-cell Lymphomas With CYCLIN D1 Gene RearrangementsSemantic proximity Read ↗

Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genes.Semantic proximity Read ↗

Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma.Semantic proximity Read ↗

Variant t(2;11)(p11.2;q13) without IGK involvement in a case of mantle cell lymphoma.Semantic proximity Read ↗

Blastoid and common variants of mantle cell lymphoma exhibit distinct immunophenotypic and interphase FISH featuresSemantic proximity Read ↗

Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profilingSemantic proximity Read ↗

SOX11 is a biomarker for cyclin D1-negative mantle cell lymphomaSemantic proximity Read ↗

Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphomaSemantic proximity Read ↗

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