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Article

Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle- cell lymphomas and t(11q13)-associated leukemias

15 Jun 1994

Abstract excerpt

Rearrangement and overexpression of CCND1 (BCL1/PRAD1), a member of the cyclin G1 gene family, are consistent features of t(11q13)-bearing B-lymphoid tumors (particularly mantle-cell lymphoma [MCL]). Its deregulation is thought to perturb the G1-S transition of the cell cycle and thereby to contribute to tumor development. As suggested by previously published studies, rearrangement of the 3' untranslated region...

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Identifiers

PMID: 8204893
DOI: 10.1182/blood.v83.12.3689.3689

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Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle- cell lymphomas and t(11q13)-associated leukemiasPMID 8204893Read ↗

Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival.Semantic proximity Read ↗

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3'UTR mediated regulation of the cyclin D1 proto-oncogene.Semantic proximity Read ↗

Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphomaSemantic proximity Read ↗

Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assaysSemantic proximity Read ↗

Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma.Semantic proximity Read ↗

Perinucleolar relocalization and nucleolin as crucial events in the transcriptional activation of key genes in mantle cell lymphomaSemantic proximity Read ↗

A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene.Semantic proximity Read ↗

t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform.Semantic proximity Read ↗

The cyclin D1 alternative transcripts [a] and [b] are expressed in normal and malignant lymphocytes and their relative levels are influenced by the polymorphism at codon 241.Semantic proximity Read ↗

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