Article

Large-scale nuclear remodeling and transcriptional deregulation occur on both derivative chromosomes after Mantle Cell Lymphoma chromosomal translocation

2019-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Recurrent chromosomal translocations are found in many blood and solid cancers. Balanced translocations, frequent in lymphoid malignancies, lead to the formation of two aberrant derivative (der) chromosomes. This event often leads to overexpression of an oncogene. In many cases, the expression of an oncogene is not enough to produce a malignant phenotype; however, most part of the studies focus...

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Literature Corpus work: 66cc5244-c8ff-5926-904d-81b646567a7d
DOI: 10.1101/2019.12.30.882407

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