Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation.

Human pathology - 1 Jun 2017

Menke Joshua R, Vasmatzis George, Murphy Stephen, Yang Lin, Menke David M, Tun Han W, King Rebecca L, Smoley Stephanie A, Ketterling Rhett P, Sukov William R

Abstract excerpt

Mantle cell lymphoma (MCL) is typically characterized by t(11;14), which places the IGH@ enhancer elements upstream of CCND1. This fusion results in up-regulation of CCND1 and consequently its protein product cyclin D1. Recent studies have shown that in MCL, mutations or translocations occurring within the 3' untranslated region (UTR) of the CCND1 gene can result in a truncated mRNA transcript that is more stable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Biopsy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to Chromosomes, Human, Pair 12

Share to Chromosomes, Human, Pair 13

Share to Cyclin D1

Share to Lymphoma, Mantle-Cell

Share to Translocation, Genetic

Source

Identifiers

PMID: 28132860
DOI: 10.1016/j.humpath.2017.01.001

Genes

CCND1
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation.PMID 28132860Read ↗

CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1− mantle cell lymphomaSemantic proximity Read ↗

Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.Semantic proximity Read ↗

Large-scale nuclear remodeling and transcriptional deregulation occur on both derivative chromosomes after Mantle Cell Lymphoma chromosomal translocationSemantic proximity Read ↗

t(11;14)-positive mantle cell lymphomas lacking cyclin D1 (CCND1) immunostaining because of a CCND1 mutation or exclusive expression of the CCND1b isoform.Semantic proximity Read ↗

Large B-cell lymphomas with CCND1 rearrangement have different immunoglobulin gene breakpoints and genomic profile than mantle cell lymphomaSemantic proximity Read ↗

CCND2 rearrangements are the most frequent genetic events in cyclin D1− mantle cell lymphomaSemantic proximity Read ↗

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic eraSemantic proximity Read ↗

Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium WorkshopSemantic proximity Read ↗

Detailed assessment of copy number alterations revealing homozygous deletions in 1p and 13q in mantle cell lymphoma.Semantic proximity Read ↗

Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridizationSemantic proximity Read ↗

Diagnostic utility of fluorescence <i>in situ</i> hybridization in mantle‐cell lymphomaSemantic proximity Read ↗

Translocation-driven chr19-der(14) interaction is associated with disease-specific transcriptional programs in mantle cell lymphomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.