Article

Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms

2024-10-11

Abstract excerpt

Translocations have largely been implicated in tumor development. However, beyond the consequences of aberrant gene expression near the breakpoint, their effects remain unexplored. In this work, we characterize the interplay between translocations, chromatin organization and gene expression using mantle cell lymphoma (MCL) as a model. We show that in vitro induced MCL-associated translocations can drive transcrip...

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Literature Corpus work: b7173e2e-a75e-5c5e-ab53-33a37930d2e1
DOI: 10.1101/2024.10.07.616925

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