Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival.

doi:10.1182/blood-2006-08-039859

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Article

Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival.

Blood - 1 Jun 2007

Wiestner Adrian, Tehrani Mahsa, Chiorazzi Michael, Wright George, Gibellini Federica, Nakayama Kazutaka, Liu Hui, Rosenwald Andreas, Muller-Hermelink H Konrad, Ott German, Chan Wing C, Greiner Timothy C, Weisenburger Dennis D, Vose Julie, Armitage James O, Gascoyne Randy D, Connors Joseph M, Campo Elias, Montserrat Emilio, Bosch Francesc, Smeland Erlend B, Kvaloy Stein, Holte Harald, Delabie Jan, Fisher Richard I, Grogan Thomas M, Miller Thomas P, Wilson Wyndham H, Jaffe Elaine S, Staudt Louis M

Abstract excerpt

A gene expression signature of tumor proliferation rate in mantle cell lymphoma (MCL) is an overriding molecular predictor of the length of survival following diagnosis. Many strongly proliferative MCL tumors have exceptionally high cyclin D1 mRNA levels and preferentially express short cyclin D1...

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Identifiers

PMID: 17299095
DOI: 10.1182/blood-2006-08-039859
PMCID: PMC1885523

Genes

CCND1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17299095-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival.PMID 17299095Read ↗

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