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Article

Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference

17 Nov 2007

Abstract excerpt

Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma with poor prognosis. Its hallmark is the translocation t(11:14)q (13;32), leading to overexpression of cyclin D1, a positive regulator of the cell cycle. As cyclin D1 up-regulation is not sufficient for inducing malignant transformation, we combined DNA microarray and RNA interference (RNAi) approaches to identify novel deregulated genes involved in the...

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PMID: 18024791
DOI: 10.1182/blood-2007-02-068791

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