Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transcriptional response to distinct growth factors is impaired in Werner syndrome cells.

Experimental gerontology - 1 Sept 2008

Lutomska Anna, Lebedev Anton, Scharffetter-Kochanek Karin, Iben Sebastian

Abstract excerpt

The Werner syndrome protein (WRN) is mutated in Werner syndrome (WS) and plays a role in telomere maintenance, DNA repair and transcription. WS represents a premature aging syndrome with severe growth retardation. Here we show that WRN is critically required to mediate the stimulatory effect of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (FGF-b) and epidermal growth factor (EGF) on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Ribosomal
Share to Exodeoxyribonucleases
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to RecQ Helicases

Share to RNA Polymerase I

Share to Werner Syndrome

Share to Werner Syndrome Helicase

Source

Identifiers

PMID: 18625297
DOI: 10.1016/j.exger.2008.06.007

Genes

WRN
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcriptional response to distinct growth factors is impaired in Werner syndrome cells.PMID 18625297Read ↗

The Werner syndrome protein is involved in RNA polymerase II transcription.Semantic proximity Read ↗

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responsesSemantic proximity Read ↗

Werner syndrome protein contains three structure-specific DNA binding domains.Semantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human agingSemantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

Genetic and epigenetic insights into Werner SyndromeSemantic proximity Read ↗

WRN mutations in Werner syndrome.Semantic proximity Read ↗

Werner SyndromeSemantic proximity Read ↗

Werner syndrome and biological ageing: a molecular genetic hypothesis.Semantic proximity Read ↗

Gene expression profiling in Werner syndrome closely resembles that of normal agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.