Werner syndrome and biological ageing: a molecular genetic hypothesis.

doi:10.1002/bies.950150609

Back to search

Article

Werner syndrome and biological ageing: a molecular genetic hypothesis.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 1993

Thweatt R, Goldstein S

Abstract excerpt

Werner syndrome (WS) is an inherited disorder that produces somatic stunting, premature ageing and early onset of degenerative and neoplastic diseases. Cultured fibroblasts derived from subjects with WS are found to undergo premature replicative senescence and thus provide a cellular model system...

Topics

Aging
Cells, Cultured
Chromosome Aberrations
Fibroblasts
Gene Expression
Genes, Suppressor
Humans
Mutation
Werner Syndrome

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.