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Article

Werner syndrome and biological ageing: a molecular genetic hypothesis.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jun 1993

Thweatt R, Goldstein S

Abstract excerpt

Werner syndrome (WS) is an inherited disorder that produces somatic stunting, premature ageing and early onset of degenerative and neoplastic diseases. Cultured fibroblasts derived from subjects with WS are found to undergo premature replicative senescence and thus provide a cellular model system to study the disorder. Recently, several overexpressed gene sequences isolated from a WS fibroblast cDNA library have...

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PMID: 8357345
DOI: 10.1002/bies.950150609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

WRN at telomeres: implications for aging and cancer.Semantic proximity Read ↗

Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.Semantic proximity Read ↗

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