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Article

IGF1 is a modifier of disease risk in hereditary non-polyposis colorectal cancer.

International journal of cancer - 15 Sept 2008

Reeves Stuart G, Rich Dominique, Meldrum Cliff J, Colyvas Kim, Kurzawski Grzegorz, Suchy Janina, Lubinski Jan, Scott Rodney J

Abstract excerpt

Patients diagnosed with HNPCC harbouring a confirmed germline mutation in DNA mismatch repair (MMR) genes have an 80% lifetime risk of developing an epithelial malignancy. There is, however, considerable variation in the age of disease onset in these patients. Insulin-like growth factor-I (IGFI) has been implicated in colorectal cancer (CRC), and elevated plasma IGFI levels are associated with both sporadic and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18623088
DOI: 10.1002/ijc.23668

Genes

IGF1
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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