Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.

European journal of human genetics : EJHG - 1 May 2009

Reeves Stuart G, Meldrum Cliff, Groombridge Claire, Spigelman Allan D, Suchy Janina, Kurzawski Grzegorz, Lubinski Jan, McElduff Patrick, Scott Rodney J

Abstract excerpt

Hereditary non-polyposis colorectal cancer (HNPCC) or Lynch syndrome is characterized by inactivating germline mutations in DNA mismatch repair genes resulting in an increased risk of developing an epithelial malignancy. There is considerable variability in disease expression observed in this syndrome, which is thought to be due to a combination of genetic and environmental factors. Alterations in the kinetics of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Gene Frequency

Share to Kaplan-Meier Estimate

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 19156174
DOI: 10.1038/ejhg.2008.239
PMCID: PMC2986255

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MTHFR 677 C>T and 1298 A>C polymorphisms and the age of onset of colorectal cancer in hereditary nonpolyposis colorectal cancer.PMID 19156174Read ↗

Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population.Semantic proximity Read ↗

Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma.Semantic proximity Read ↗

Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients.Semantic proximity Read ↗

Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.Semantic proximity Read ↗

DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.Semantic proximity Read ↗

DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.Semantic proximity Read ↗

MTHFR C677T and A1298C polymorphism's effect on risk of colorectal cancer in Lynch syndrome.Semantic proximity Read ↗

Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age.Semantic proximity Read ↗

Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy.Semantic proximity Read ↗

The -149C>T SNP within the DeltaDNMT3B gene, is not associated with early disease onset in hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome.Semantic proximity Read ↗

p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.