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Article

IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study Project.

Carcinogenesis - 1 Apr 2006

Cleveland Rebecca J, Gammon Marilie D, Edmiston Sharon N, Teitelbaum Susan L, Britton Julie A, Terry Mary Beth, Eng Sybil M, Neugut Alfred I, Santella Regina M, Conway Kathleen

Abstract excerpt

Insulin-like growth factor I (IGF-I) is an important regulator of growth and differentiation and is a potent mitogen for human breast cancer cells. Recent investigations suggest an association between cytosine-adenine dinucleotide (CA)n repeat polymorphisms of the IGF1 gene and IGF-I levels and further evidence indicates that genotype may influence breast cancer risk. We assessed the relation between IGF1 (CA)n...

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PMID: 16332723
DOI: 10.1093/carcin/bgi294

Genes

IGF1

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