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Article

IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer.

Journal of the National Cancer Institute - 18 Jan 2006

Zecevic Maja, Amos Christopher I, Gu Xiangjun, Campos Imelda M, Jones J Shawn, Lynch Patrick M, Rodriguez-Bigas Miguel A, Frazier Marsha L

Abstract excerpt

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Insulin-like growth factor-I (IGF-I) is involved in colorectal carcinogenesis, and elevated plasma IGF-I levels are associated with sporadic colorectal cancer (CRC) risk. We investigated the relationship between IGF1 promoter cytosine-adenine (CA) dinucleotide-repeat...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16418517
DOI: 10.1093/jnci/djj016

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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