Article
The genetic basis of colorectal cancer in a population-based incident cohort with a high rate of familial disease.
Gut - 1 Oct 2010
Woods M O, Younghusband H B, Parfrey P S, Gallinger S, McLaughlin J, Dicks E, Stuckless S, Pollett A, Bapat B, Mrkonjic M, de la Chapelle A, Clendenning M, Thibodeau S N, Simms M, Dohey A, Williams P, Robb D, Searle C, Green J S, Green R C
Abstract excerpt
BACKGROUND AND AIMS: Colorectal cancer (CRC) is the second most frequent cancer in developed countries. Newfoundland has the highest incidence of CRC in Canada and the highest rate of familial CRC yet reported in the world. To determine the impact of mutations in known CRC susceptibility genes and the contribution of the known pathways to the development of hereditary CRC, an incident cohort of 750 patients with...
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