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Article

Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

BMC cancer - 5 May 2010

van Roon Eddy H J, van Puijenbroek Marjo, Middeldorp Anneke, van Eijk Ronald, de Meijer Emile J, Erasmus Dianhdra, Wouters Kim A D, van Engeland Manon, Oosting Jan, Hes Frederik J, Tops Carli M J, van Wezel Tom, Boer Judith M, Morreau Hans

Abstract excerpt

BACKGROUND: To investigate the etiology of MLH1 promoter methylation in mismatch repair (MMR) mutation-negative early onset MSI-H colon cancer. As this type of colon cancer is associated with high ages, young patients bearing this type of malignancy are rare and could provide additional insight into the etiology of sporadic MSI-H colon cancer. METHODS: We studied a set of 46 MSI-H colon tumors cases with MLH1...

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Identifiers

PMID: 20444249
DOI: 10.1186/1471-2407-10-180
PMCID: PMC2880297

Genes

MLH1
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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