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Article

Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers.

European journal of human genetics : EJHG - 1 Aug 2011

Houlle Solene, Charbonnier Françoise, Houivet Estelle, Tinat Julie, Buisine Marie-Pierre, Caron Olivier, Benichou Jacques, Baert-Desurmont Stéphanie, Frebourg Thierry

Abstract excerpt

Several studies have reported that, in Lynch syndrome resulting from mutations of the mismatch repair (MMR) genes, a CA repeat ≤17 within the IGF1 promoter, SNPs within the xenobiotic metabolizing enzyme gene CYP1A1 and SNPs on 8q23.3 and 11q23.1 modify colorectal cancer (CRC) risk in MMR mutation carriers. We analysed the impact of these polymorphisms on CRC risk in 748 French MMR mutation carriers derived from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21407259
DOI: 10.1038/ejhg.2011.44
PMCID: PMC3172927

Genes

MSH6
IGF1
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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